Journal
ANESTHESIA AND ANALGESIA
Volume 113, Issue 4, Pages 742-748Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1213/ANE.0b013e3182288e01
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- Spanish Government [PI070840, PI070481]
- Spanish Society of Pneumology and Thoracic Surgery (SEPAR) [06/121]
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BACKGROUND: Ischemia-reperfusion lung injury is doubly important in thoracic surgery because of the associated ventilation damage to 1 lung. In this study we evaluated the cytoprotective effects of sevoflurane in a pulmonary autotransplant model in pigs. METHODS: Twenty Large White pigs undergoing pneumonectomy plus lung autotransplant were divided into 2 10-member groups on the basis of the anesthetic received (propofol or sevoflurane). Proinflammatory mediators, oxidative stress, nitric oxide metabolism, and hemodynamic and blood variables were measured at 5 different time points. RESULTS: There was an increase of oxidative stress markers and proinflammatory mediators in the propofol group, whereas the hemodynamic variables were similar in both groups. CONCLUSIONS: We demonstrated that sevoflurane decreased the inflammatory response and oxidative stress in a live ischemia-reperfusion lung model. (Anesth Analg 2011;113:742-8)
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