Two-dimensional spectroscopy with parallel acquisition of 1H-X and 19F-X correlations

Two-dimensional NMR spectra correlating both H-1 and F-19 nuclei with either C-13 or N-15, are recorded at the same time, using a 600-MHz broadband radio frequency probe feeding independent H-1 and F-19 receiver channels. This technique, known as parallel acquisition NMR spectroscopy (PANSY), speeds up multidimensional NMR and is compatible with other fast-acquisition schemes. The method is illustrated with single-bond (HSQC) and multiple-bond (HMBC) experiments on 2-bromophenyl-3-trifluoromethyl5-methylpyrazole, giving simultaneous H-1-X and F-19-X correlation spectra (X = (13C) or N-15). Copyright (c) 2007 John Wiley & Sons, Ltd.