Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 114, Issue 5, Pages 657-663Publisher
SPRINGER WIEN
DOI: 10.1007/s00702-006-0607-2
Keywords
ApoA-I; chlorpromazine; clozapine; proteomics; schizophrenia
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This study aims to identify the effects of antipsychotics on plasma proteins, and on the proteins associated with schizophrenia. We applied proteomics technology to screen protein aberrations in Sprague-Dawley rats treated with antipsychotics and schizophrenic patients undergoing medication. ApoA-I was found significantly increased in the chlorpromazine-treated rats and decreased in the patients with treatment-resistant schizophrenia, which suggest that decreased levels of apoA-I might be associated with the pathology of schizophrenia and that chlorpromazine increases apoA-I levels as part of its therapeutic action.
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