Journal
EUROPEAN POLYMER JOURNAL
Volume 43, Issue 5, Pages 1602-1608Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2007.02.030
Keywords
hydroxyapatite; surface modification; nanocomposites; poly(epsilon-caprolactone); grafting
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We describe the effect of surface-modified hydroxyapatite (HAp) nano-crystals on biocompatibility of a new-type nanocomposite consisting of poly(epsilon-caprolactone) (PCL) and FlAp. Surface-modified hydroxyapatite (HAp) nano-crystals were prepared by chemically grafting PCL on HAp surfaces. Time-dependent phase monitoring indicated that PCL surface-grafting contributed to the enhanced dispersion of HAp at nano-level in the PCL solution. The protein adhesion and cell experiments showed that the presence of PCL-grafted HAp nano-crystals in nanocomposites contributed to the enhanced biocompatibility. PCL-grafted HAp in nanocomposites provided more favorable environments for protein adsorption, compared with unmodified HAp. Nanocomposites containing PCL-grafted nanophase HAp showed positive effects on adhesion and proliferation of NIH3T3 fibroblasts. (C) 2007 Elsevier Ltd. All rights reserved.
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