Journal
GENETICS
Volume 176, Issue 1, Pages 327-342Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.106.065037
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Funding
- NIGMS NIH HHS [R01 GM060777, R01 GM050428, GM50428, GM60777, R29 GM050428] Funding Source: Medline
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Longitudinal samples of DNA sequences, the DNA sequences sampled from the same population at different time points, have increasingly been used to study the evolutionary process of fast-evolving organisms, e.g., RNA Virus, in recent years. We propose in this article several methods for testing genetical isochronism or detecting significant genetical heterochronism in this type of sample. These methods can be used to determine the necessary sample size and sampling interval in experimental design or to combine genetically isochronic samples for better data analysis. We investigate the properties of these test statistics, including their powers of detecting heterochronism, assuming different evolutionary processes using simulation. The possible choices and usages of these test statistics are discussed.
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