Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 12, Issue -, Pages 4011-4019Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/2367
Keywords
Akt; neoplasia; tumor; cancer; breast; review
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The PI3K/ Akt pathway plays a central role in a variety of cellular processes including cell growth, proliferation, motility and survival in both normal and tumor cells. The PI3K/ Akt pathway is also instrumental in epithelial mesenchymal transitions and in angiogenesis during tumorigenesis. Many of the transforming events in breast cancer are a result of enhanced signaling of the PI3K/ Akt pathway. Akt therefore is considered to be a rational target for cancer therapies and inhibitors of the PI3K/ Akt pathway have been identified. In this review, we discuss the recent information about the functional roles of PI3K/ Akt pathway in tumorigenesis and progression of breast cancer.
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