Journal
TRENDS IN CARDIOVASCULAR MEDICINE
Volume 17, Issue 4, Pages 113-118Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2007.03.001
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Atherosclerosis is an inflammatory disease of the arterial wall where both innate and adaptive T-cell-driven immunoinflammatory responses contribute to disease development. Recent studies from several groups suggest that subtypes of T cells, called regulatory T cells, previously shown to maintain immunologic tolerance, control the development and progression of atherosclerosis. Here, we summarize the current knowledge on the regulatory T-cell response in the context of atherosclerosis and the accumulating evidence for its central role in counters acting disease initiation and progression.
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