Journal
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Volume 618, Issue 1-2, Pages 18-29Publisher
ELSEVIER
DOI: 10.1016/j.mrfmmm.2006.10.006
Keywords
INO80; SWR1; ATP-dependent chromatin remodeling; DNA repair; histone variant; actin; Arps; Rvb1; Rvb2; H2AZ; H2AX
Funding
- NCI NIH HHS [K22 CA100017-03, K22 CA100017] Funding Source: Medline
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ATP-dependent chromatin remodeling complexes contain ATPases of the Swi/Snf superfamily and alter DNA accessibility of chromatin in an ATP-dependent manner. Recently characterized INO80 and SWR1 complexes belong to a subfamily of these chromatin remodelers and are characterized by a split ATPase domain in the core ATPase subunit and the presence of Rvb proteins. INO80 and SWR1 complexes are evolutionarily conserved from yeast to human and have been implicated in transcription regulation, as well as DNA repair. The individual components, assembly patterns, and molecular mechanisms of the INO80 class of chromatin remodeling complexes are discussed in this review. (C) 2007 Elsevier B.V. All rights reserved.
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