Unified methodology of neural analysis in decision support systems built for pharmaceutical technology

The objective of this study was to create universal methodology of artificial neural networks (ANNs) application in construction of decision support systems designed for various dosage forms. Two different dosage forms (solid dispersions and microemulsions) were modeled with use of the same methodology, software and hardware environments. Completely different models prepared confirmed their generalization ability both for solid dosage forms (solid dispersions) and liquid dosage forms (microemulsions). ME-expert and SD_ expert systems basing on the neural expert committees were created. In the pilot study their application allowed for appropriate choice of qualitative and quantitative composition of particular pharmaceutical formulation. It was also proposed that ME expert and SD_ expert might provide in silico formulation procedures. Unified methodology of neural modeling in pharmaceutical technology was confirmed to be effective in providing valuable tools for pharmaceutical product development. (C) 2006 Elsevier Ltd. All rights reserved.