Journal
AUTOPHAGY
Volume 3, Issue 3, Pages 238-240Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.3710
Keywords
mTOR; rapamycin; energy; amino acids; AICAR; metformin; hepatocytes; HeLa cells; HT-29 cells; LKB1
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Autophagy is inhibited by TOR-dependent signaling. Interruption of signalling by rapamycin is known to stimulate autophagy, both in mammalian cells and in yeast. However, inactivation of TOR by AMPK has yielded controversial results in the literature with regard to its effect on autophagy: activation of autophogy in yeast but inhibition in hepatocytes. In a recent study, carried out with hepatocytes, HT-29 cells, and HeLa cells, the possible role of AMPK in the control of mammalian autophagy was reexamined. The data suggest that in mammalian cells, as in yeast, AMPK is required for autophagy.
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