Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 8, Issue 5, Pages 379-393Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2163
Keywords
-
Categories
Funding
- NIGMS NIH HHS [R37 GM024364, R01 GM060678] Funding Source: Medline
- Telethon [GGP06044] Funding Source: Medline
Ask authors/readers for more resources
In eukaryotes, the spindle-assembly checkpoint ( SAC) is a ubiquitous safety device that ensures the fidelity of chromosome segregation in mitosis. The SAC prevents chromosome mis-segregation and aneuploidy, and its dysfunction is implicated in tumorigenesis. Recent molecular analyses have begun to shed light on the complex interaction of the checkpoint proteins with kinetochores - structures that mediate the binding of spindle microtubules to chromosomes in mitosis. These studies are finally starting to reveal the mechanisms of checkpoint activation and silencing during mitotic progression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available