Journal
NANO LETTERS
Volume 7, Issue 5, Pages 1419-1423Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl070126v
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- Medical Research Council [MC_U105178791] Funding Source: researchfish
- Medical Research Council [MC_U105178791] Funding Source: Medline
- MRC [MC_U105178791] Funding Source: UKRI
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A 110 kDa (ca. 5 nm in diameter) bivalent paramagnetic nanoprobe for detecting cell death using magnetic resonance imaging (MRI) is described, in which two biotinylated C2A domains of the protein synaptotagmin-I were complexed with a single avidin molecule, which had been labeled with gadolinium chelates. This nanoprobe bound with high affinity and specificity to the phosphatidylserine exposed by dying cells and was demonstrated to allow MRI detection of apoptotic tumor cells in vitro.
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