Journal
AMINO ACIDS
Volume 32, Issue 4, Pages 603-606Publisher
SPRINGER
DOI: 10.1007/s00726-006-0448-1
Keywords
oxidative-stress; non-replicative senescence; post-translation modification
Categories
Ask authors/readers for more resources
The major enzyme of the methionine sulfoxide reductase (Msr) system is MsrA. Senescing msrA knockout mother yeast cells accumulated significant amounts of protein-carbonyl both at 5 generation-old (young) and 21 generation-old (old) cultures, while the control mother cells showed significant levels of protein-carbonyl mainly in the old culture. The Msr activities of both yeast strains declined with age and exposure of cells to H2O2 caused an accumulation of protein-carbonyl especially in the msrA knockout strain. It is suggested that a compromised MsrA activity may serve as a marker for non-replicative aging.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available