Journal
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
Volume 83, Issue 5, Pages 127-135Publisher
JAPAN ACAD
DOI: 10.2183/pjab.83.127
Keywords
chiral discrimination; helically chiral diastereomer; Induced Chiral Fields; reversed-phase HPLC; fluorescent and chiral labeling reagent; modified Mosher's reagent
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The development of highly potent chiral discrimination methods that solve the problems of the diastereomer method, in which it is impossible to discriminate the diastereomers having chiral centers separated by more than four bonds, is described. On the basis of the results obtained, a new hypothesis, Induced Chiral Fields that the achiral reversed phase can provide chiral fields depending on the structures of the eluents, is proposed to explain the significant results of separation of the diastereomers derived from newly developed chiral and fluorescent labeling reagents and optical isomers by reversed-phase HPLC, which was hitherto impossible.
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