Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 10, Issue -, Pages 2985-2996Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S79605
Keywords
cancer nanotechnology; drug delivery; surface modification; polydopamine; malignant melanoma
Funding
- Guangdong Natural Science Foundation [2014A030313758]
- Doctoral Fund of Ministry of Education of China [20120002120020]
- Science, Technology & Innovation Commission of Shenzhen Municipality [JCYJ20120616213411826, JCYJ20140417115840285]
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To enhance the therapeutic effects of chemotherapy on malignant melanoma, paclitaxel (PTX)-loaded methoxy poly(ethylene glycol)-b-poly(epsilon-caprolactone) nanoparticles b-PCL NPs) that had their surfaces modified with polydopamine (PTX-loaded MPEG-PCL NPs@PDA) were prepared as drug vehicles. The block copolymer MPEG-b-PCL was synthesized by ring-opening polymerization and characterized by proton nuclear magnetic resonance spectroscopy and gel permeation chromatography. The PTX-loaded NPs were prepared by a modified nanoprecipitation technique. The PTX-loaded NPs and PTX-loaded NPs@PDA were characterized in terms of size and size distribution, zeta potential, surface morphology, drug encapsulation efficiency, and drug release. Confocal laser scanning microscopy showed that coumarin-6-loaded NPs@PDA could be internalized by human melanoma cell line A875 cells. The cellular uptake efficiency of NPs was greatly enhanced after PDA modification. The antitumor efficacy of the PTX-loaded NPs@PDA was investigated in vitro by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and in vivo by a xenograft tumor model. The PTX-loaded NPs@PDA could significantly inhibit tumor growth compared to Taxol (R) and precursor PTX-loaded NPs. All the results suggested that the PTX-loaded MPEG-b-PCL NPs that had their surfaces modified with PDA are promising nanocarriers for malignant melanoma therapy.
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