Journal
CLINICA CHIMICA ACTA
Volume 380, Issue 1-2, Pages 24-30Publisher
ELSEVIER
DOI: 10.1016/j.cca.2007.01.026
Keywords
adiponectin; anti-inflammatory; cardioprotection; biomarker
Categories
Funding
- NHLBI NIH HHS [R01 HL077774, P01 HL066957, HL77774, P01 HL066957-01A10004, R01 HL077774-01A1, HL66957] Funding Source: Medline
- NIAMS NIH HHS [R01 AR040197-09, R01 AR040197, AR40197] Funding Source: Medline
- NIA NIH HHS [R01 AG015052-02, R37 AG015052, AG15052, R01 AG015052] Funding Source: Medline
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Obesity is characterized by low-grade systemic inflammation. Adiponectin is an adipose tissue-derived hormone, which is downregulated in obesity. Adiponectin displays protective actions on the development of various obesity-linked diseases. Several clinical studies demonstrate the inverse relationship between plasma adiponectin levels and several inflammatory markers including C-reactive protein. Adiponectin attenuates inflammatory responses to multiple stimuli by modulating signaling pathways in a variety of cell types. The anti-inflammatory properties of adiponectin may be a major component of its beneficial effects on cardiovascular and metabolic disorders including atherosclerosis and insulin resistance. In this review, we focus on the role of adiponectin in regulation of inflammatory response and discuss its potential as an antiinflammatory marker. (c) 2007 Elsevier B.V. All rights reserved.
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