Journal
BLOOD CELLS MOLECULES AND DISEASES
Volume 38, Issue 3, Pages 258-268Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bcmd.2006.12.003
Keywords
vascular endothelial growth factor; ligand; receptor; angiogenesis; review
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VEGF signaling often represents a critical rate-limiting step in physiological angiogenesis. The VEGF family comprises seven secreted glycoproteins that are designated VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, placental growth factor (PIGF) and VEGF-F. The VEGF family members bind their cognate receptors. The receptors identified so far are designated VEGFR-1, VEGFR-2, VEGFR-3 and the neuropilins (NP-1 and NP-2). We review in this article the biology of the VEGF ligands and the receptors. (c) 2007 Elsevier Inc. All rights reserved.
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