Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 81, Issue 5, Pages 679-684Publisher
WILEY
DOI: 10.1038/sj.clpt.6100098
Keywords
-
Categories
Ask authors/readers for more resources
The aim of this study was to determine the influence of amiodarone on the pharmacokinetics of simvastatin and pravastatin in humans. This was a prospective, crossover, randomized, open-label study performed in 12 healthy volunteers comparing the pharmacokinetics of a single oral dose of simvastatin ( 40 mg) or pravastatin ( 40 mg) taken alone and after 3 days of amiodarone ( 400 mg/day). Amiodarone increased simvastatin acid AUC ( area under the plasma concentration-time curve)(0-24h), peak plasma concentration ( C-max), and t(1/2) by 73% ( P = 0.02), 100% ( P = 0.02), and 48% ( P = 0.06), respectively, whereas it did not significantly alter pravastatin pharmacokinetics. Point estimates and 90% confidence intervals for simvastatin acid, simvastatin lactone, and pravastatin AUC(0-24) h were 154% ( 109-216%), 155% ( 109-227%), and 86% ( 63-118%), respectively. If amiodarone and a statin have to be simultaneously prescribed, pravastatin should be preferred to simvastatin in order to avoid a drug interaction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available