Journal
AMERICAN JOURNAL OF HUMAN GENETICS
Volume 80, Issue 5, Pages 948-956Publisher
CELL PRESS
DOI: 10.1086/513477
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Funding
- NHGRI NIH HHS [HG002154, R01 HG002154] Funding Source: Medline
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A proper understanding of population genetic stratification - differences in individual ancestry within a population - is crucial in attempts to find genes for complex traits through association mapping. We report on genomewide typing of similar to 10,000 single-nucleotide polymorphisms in 297 individuals, to explore population structure in Europeans of known and unknown ancestry. The results reveal the presence of several significant axes of stratification, most prominently in a northern-southeastern trend, but also along an east-west axis. We also demonstrate the selection and application of EuroAIMs ( European ancestry informative markers) for ancestry estimation and correction. The Coriell Caucasian and CEPH ( Centre d'E tude du Polymorphisme Humain) Utah sample panels, often used as proxies for European populations, are found to reflect different subsets of the continent's ancestry.
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