Journal
HEART AND VESSELS
Volume 22, Issue 3, Pages 170-177Publisher
SPRINGER
DOI: 10.1007/s00380-006-0954-9
Keywords
rapid ventricular pacing; left ventricular arterial coupling; pump dysfunction; heart failure
Funding
- NHLBI NIH HHS [P01 HL078825-01] Funding Source: Medline
- NIEHS NIH HHS [P01 ES011860-01A1] Funding Source: Medline
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The objective of this study was to define alterations in ventricular-arterial (V-A) coupling early in the development of tachycardia-induced heart failure (HF). Although HF is characterized by impaired V-A coupling, the temporal relationship of these derangements to overt left ventricular (LV) dysfunction is unknown. Six anesthetized dogs instrumented with LV manometers and piezoelectric crystals were studied before and after 24 h of rapid ventricular pacing (RVP). V-A coupling was indexed by the ratio between the end-systolic pressure-volume relation slope (endsystolic elastance, E-ES) and effective arterial elastance (E-A), and mechanical efficiency by the ratio of stroke work (SW) to pressure-volume area (PVA). After RVP, there was no significant depression of LV function, but E and total peripheral resistance (R-T) were increased (P < 0.05), indicating increased arterial load. After RVP, E-ES/E-A and SW/PVA were maintained during unstressed conditions, but upon changes in load induced by phenylephrine, E-ES/E-A declined more precipitously with equivalent increases in RT (slope E-ES/E-A RT relation -16.7 +/- 4.6 vs -5.8 4.0ml/mmHg-min, P < 0.025). Furthermore, after RVP there was significant (P < 0.05) blunting of dobutamine-induced augmentation of E-ES, E-ES/E-A, and SW/PVA. Thus, after RVP there was a distinct loss of V-A coupling reserve during afterload and catecholamine stress. V-A coupling defects occur early in the development of tachycardia-induced HF prior to significant pump dysfunction, and are manifested primarily during hemodynamic and inotropic stress.
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