Journal
LEUKEMIA
Volume 21, Issue 5, Pages 860-867Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.leu.2404630
Keywords
Oct-4; Nanog; SSEA-4; VSELs; embryonic stem cells
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Funding
- NCI NIH HHS [R01 CA106281-01] Funding Source: Medline
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Accumulating evidence demonstrates that adult tissues contain a population of stem cells that express early developmental markers such as stage-specific embryonic antigen and transcription factors Oct-4 and Nanog. These are the markers characteristic for embryonic stem cells, epiblast stem cells and primordial germ cells. The presence of these stem cells in adult tissues including bone marrow, epidermis, bronchial epithelium, myocardium, pancreas and testes supports the concept that adult tissues contain some population of pluripotent stem cells that is deposited in embryogenesis during early gastrulation. In this review we will discuss these data and present a hypothesis that these cells could be direct descendants of the germ lineage. The germ lineage in order to pass genes on to the next generations creates soma and thus becomes a 'mother lineage' for all somatic cell lineages present in the adult body.
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