Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 11, Issue 3, Pages 592-597Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op6002743
Keywords
-
Categories
Ask authors/readers for more resources
The mechanochemical technique of ball milling has been applied to the asymmetric opening of meso-anhydrides, mediated by the cinchona alkaloid quinidine. A simple workup procedure affords the products, optically active dicarboxylic acid monoesters, in high yields, with up to 64% ee. With most substrates no column chromatography was needed. A range of various alcohols, as well as anhydrides, reacted well thus demonstrating the scope of this methodology. Even mixtures of purely solid components react, and no solvent is required ( except during the workup). The possible use of almost equimolar amounts of starting materials significantly simplifies the product isolation compared to the standard solution reaction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available