Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 12, Issue 3, Pages -Publisher
SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.2744025
Keywords
brain tissue; chemotherapy; pharmacokinetics; spectroscopy
Funding
- NCI NIH HHS [F31CA119916] Funding Source: Medline
- NIGMS NIH HHS [K08 GM000698, K08 GM000698-05] Funding Source: Medline
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The understanding of drug delivery to organs, such as the brain, has been hampered by the inability to measure tissue drug concentrations in real time. We report an application of an optical spectroscopy technique that monitors in vivo the real-time drug concentrations in small volumes of brain tissue. This method will facilitate development of new protocols for delivery of drugs to treat brain cancers. The delivery of many anticancer drugs to the brain is limited by the presence of the blood-brain barrier (BBB). Mitoxantrone (MTX) is a water-soluble anticancer drug that poorly penetrates the BBB. It is preliminarily determined in an animal model that the brain tissue uptake of chemotherapy agents-in this demonstration, MTX-delivered intra-arterially is enhanced when the BBB is disrupted. (C) 2007 Society of Photo-Optical Instrumentation Engineers.
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