Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 10, Issue -, Pages 765-774Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S66058
Keywords
sulphated zirconia; nanoparticles; antimicrobial; anticancer
Ask authors/readers for more resources
Nanoparticle sulphated zirconia with Bronsted acidic sites were prepared here by an impregnation reaction followed by calcination at 600 degrees C for 3 hours. The characterization was completed using X-ray diffraction, thermal gravimetric analysis, Fourier transform infrared spectroscopy, Brunner-Emmett-Teller surface area measurements, scanning electron microscopy with energy dispersive X-ray spectroscopy, and transmission electron microscopy. Moreover, the anticancer and antimicrobial effects were investigated for the first time. This study showed for the first time that the exposure of cancer cells to sulphated zirconia nanoparticles (3.9-1,000 mu g/mL for 24 hours) resulted in a dose-dependent inhibition of cell growth, as determined by (4,5dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide assays. Similar promising results were observed for reducing bacteria functions. In this manner, this study demonstrated that sulphated zirconia nanoparticles with Bronsted acidic sites should be further studied for a wide range of anticancer and antibacterial applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available