Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 42, Issue 5, Pages 903-911Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2007.03.738
Keywords
SERCA2a; sarcolipin; phospholamban; calcium; regulation
Categories
Funding
- NHLBI NIH HHS [R01 HL064140, R01 HL064140-09, R01-HL64140, R01 HL088555, R01 HL088555-01A1] Funding Source: Medline
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The cardiac sarcoplasmic reticulum calcium ATPase (SERCA2a) plays a critical role in maintaining the intracellular calcium homeostasis during cardiac contraction and relaxation. It has been well documented over the years that altered expression and activity of SERCA2a can lead to systolic and diastolic dysfunction. The activity of SERCA2a is regulated by two structurally similar proteins, phospholamban (PLB) and sarcolipin (SLN). Although, the relevance of PLB has been extensively studied over the years, the role SLN in cardiac physiology is an emerging field of study. This review focuses on the advances in the understanding of the regulation of SERCA2a by SLN and PLB. In particular, it highlights the similarities and differences between the two proteins and their roles in cardiac patho-physiology. (C) 2007 Elsevier Inc. All rights reserved.
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