Journal
CELL CYCLE
Volume 6, Issue 9, Pages 1049-1052Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.6.9.4229
Keywords
cytokines; oxygen; pulmonary; cell death; apoptosis; necrosis
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Funding
- NHLBI NIH HHS [HL-61904, HL-56389, HL-64242, HL-74195] Funding Source: Medline
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Hyperoxia-induced acute lung injury (HALI) is characterized by an influx of inflammatory cells, increased pulmonary permeability, endothelial and epithelial cell death. In a murine model and in vitro, we found Angiopoietin 2 to be a critical mediator of lung oxidant injury, inflammation, edema, and regulator of necrotic cell death pathways. The clinical significance of our findings was highlighted by the detection of increased Angiopoietin 2 levels in patients with ALI.
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