Journal
BRAIN & DEVELOPMENT
Volume 29, Issue 4, Pages 224-226Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.braindev.2006.08.011
Keywords
cerebellitis; anti-glutamate receptor antibody; steroid; obstructive hydrocephalus
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A 13-year-old boy presented with a six-day history of headache and gradually developed severe meningeal irritation symptoms. Brain magnetic resonance imaging revealed left cerebellar swelling and obstructive hydrocephalus. Then he showed transient ataxia, but recovered without any sequelae soon after high dose steroid therapy. IgG type of autoantibodies against glutamate receptor 62 (GluR delta 2) were detected in the serum, but not in the cerebrospinal fluid in his early clinical course. It was suggested that autoantibodies against GluR delta 2 might not have injured the tissue due to the immunological action, but might be induced as a consequence of cerebellar damage. Early steroid treatment for acute cerebellitis might have been effective to prevent the progress of the disease and improve the prognosis. (c) 2006 Elsevier B.V. All rights reserved.
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