Journal
BRAIN & DEVELOPMENT
Volume 29, Issue 4, Pages 254-256Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.braindev.2006.09.004
Keywords
acute cerebellar ataxia; cerebellitis; glutamate receptor delta 2 autoantibody
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Acute cerebellar ataxia is usually a self-limited benign disease, which may develop in children after certain viral infections or vaccinations. There are several reports of acute cerebellar ataxia associated with autoantibodies. Glutamate receptor 82, a member of the glutamate receptor family, is predominantly expressed in cerebellar Purkinje cells and plays a crucial role in cerebellar functions. To date anti-GluR delta 2 autoantibody was detected in a patient with chronic cerebellitis. Herein, an 18-month-old boy presented with cerebellar ataxia 9 days following a mild respiratory tract infection. Although cerebellar ataxia gradually improved, it worsened yet again following mumps and varicella virus infection. Cerebro-spinal fluid examination and magnetic resonance imaging of the brain demonstrated pleocytosis and meningeal enhancement, respectively. Furthermore, glutamate receptor 62 autoantibody was detected in serum and cerebro-spinal fluid. Thus, we believe that the glutamate receptor 62 autoantibody may play a role in cerebellar ataxia and consecutive cerebellitis. (c) 2006 Elsevier B.V. All rights reserved.
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