Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 8, Issue 5, Pages 369-378Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2146
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Funding
- Medical Research Council [G0300415, G0500220] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- MRC [G0500220, G0300415] Funding Source: UKRI
- Medical Research Council [G0300415, G0500220] Funding Source: researchfish
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Transformations from one tissue type to another make up a well established set of phenomena that can be explained by the principles of developmental biology. Although these phenomena might be rare in nature, we can now imagine the possibility of deliberately reprogramming cells from one tissue type to another by manipulating the expression of transcription factors. This approach could generate new therapies for many human diseases.
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