Journal
EXPERIMENTAL GERONTOLOGY
Volume 42, Issue 5, Pages 391-395Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2006.11.010
Keywords
aging B lymphopoieis; leukemia; hematopoiesis
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Funding
- NIA NIH HHS [R01 AG021450] Funding Source: Medline
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The production of B lymphocytes begins to decline steadily early in adult life and is severely compromised in the elderly. This occurrence has been attributed to intrinsic defects in early hematopoietic progenitors and B cell precursors as well as to microenvironmental changes in aged bone marrow. The aim of this review is to present an overview of B lymphocyte senescence and its underlying causes and to discuss its impact on immune function and leukemogenesis in aged individuals. (C) 2006 Elsevier Inc. All rights reserved.
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