Journal
MOLECULES
Volume 12, Issue 5, Pages 1147-1152Publisher
MDPI
DOI: 10.3390/12051147
Keywords
Platycodi radix; neuroprotective; triterpenes saponin; glutamate-induced toxicity
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During our investigation of the neuroprotective activity of Platycodi radix we found that an aqueous extract of this folk medicine exhibited significant protection against glutamate-induced toxicity in primary cultured rat cortical cells. In order to clarify the neuroprotective mechanism(s) of this observed effect, activity-guided isolation was performed to seek and identify active fractions and components. By such fractionation, four known triterpene saponin compounds - platycodins A, C and D and deapioplatycodin D - were isolated from the n-butanol fraction. Among these four compounds, platycodin A exhibited significant neuroprotective activities against glutamate-induced toxicity, exhibiting cell viability of about 50 %, at concentrations ranging from 0.1 mu M to 10 mu M. Therefore, the neuroprotective effect of Platycodi radix might be due to the inhibition of glutamate-induced toxicity by the saponin compounds it contains.
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