Journal
JOURNAL OF SEPARATION SCIENCE
Volume 30, Issue 7, Pages 1029-1036Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.200600358
Keywords
background contamination; sample preparation; solid-phase extraction; solid-phase microextraction
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Funding
- NIEHS NIH HHS [P30 ES005022, ES05022] Funding Source: Medline
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A study to identify the sources of background contamination from SPE, using a C-18 sorbent, and solid-phase microextraction (SPME), using a 70 Pin carbowax/divinylbenzene (CW/DVB) fiber, was carried out. To determine the source of contamination, each material used in the procedure was isolated and examined for their contribution. The solid-phase column components examined were: sorbent material and frits, column housings and each solvent used to elute analytes off the column. The components examined in the SPME procedure were: SPME fiber, SPME vials, water (HPLC grade), and salt (sodium chloride) used to increase the ionic strength. The majority of the background contaminants from SPE were found to be from the SPE sorbent material and frits. The class of contaminants extracted during a blank extraction were phthalates and other plasticizers used during the manufacturing process. All had blank levels corresponding to measured concentrations below 2 ng/mL, except for undecane, which had a concentration of 5.4 ng/mL. The most prevalent contaminants in the SPME blank procedure are 1,9-nonanediol, a mixture of phthalates and highly bis-substituted phenols. All the concentrations were below 2 ng/mL, with the exception of bis (2-ethylhexyl) phthalate, which had concentrations ranging from 5 to 20 ng/mL.
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