Journal
JOURNAL OF NEUROCHEMISTRY
Volume 101, Issue 4, Pages 906-917Publisher
WILEY
DOI: 10.1111/j.1471-4159.2006.04401.x
Keywords
collapsin response mediator protein 2; crystal structure; growth cone guidance; neuronal regeneration; tetramer; TIM barrel
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Funding
- Wellcome Trust Funding Source: Medline
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Axonal growth cone guidance is a central process in nervous system development and repair. Collapsin response mediator protein 2 (CRMP-2) is a neurite extension-promoting neuronal cytosolic molecule involved in the signalling of growth inhibitory cues from external stimuli, such as semaphorin 3A and the myelin-associated glycoprotein. We have determined the crystal structure of human tetrameric CRMP-2, which is structurally related to the dihydropyriminidases; however, the active site is not conserved. The wealth of earlier functional mapping data for CRMP-2 are discussed in light of the three-dimensional structure of the protein. The differences in oligomerisation interfaces between CRMP-1 and CRMP-2 are used to model CRMP-1/2 heterotetramers.
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