Journal
INTERNATIONAL UROGYNECOLOGY JOURNAL
Volume 18, Issue 5, Pages 555-563Publisher
SPRINGER LONDON LTD
DOI: 10.1007/s00192-006-0288-2
Keywords
biomaterial; dermal collagen; uterine; prolapse; reconstructive surgical procedures; small-intestine submucosa; surgical mesh; heterologous; transplantation
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Xenografts, bovine or porcine acellular collagen bioprostheses derived from dermis, pericardium, or small-intestine submucosa, were introduced to overcome synthetic mesh-related complications. Although there are eight commercially available xenografts, there is a paucity of empiric information to justify their use instead of the use of synthetic grafts. In addition, limited data are available about which graft characteristics are important and whether graft-reinforced repairs reduce recurrences and improve outcomes. To address these knowledge gaps, we conducted a Medline search of published reports on xenografts in animal and human trials. Histologic host response to implanted xenograft material depends primarily on chemical cross-linking and porosity, and it is limited to four responses: resorption, incorporation, encapsulation, and mixed. No clinical data unequivocally demonstrate an improved benefit to graft-reinforced repair.
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