Journal
NATURE IMMUNOLOGY
Volume 8, Issue 5, Pages 532-539Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1456
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Funding
- NIGMS NIH HHS [R01GM57411, R01GM23547] Funding Source: Medline
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P-selectin glycoprotein ligand 1 (PSGL-1) is central to the trafficking of immune effector cells to areas of inflammation through direct interactions with P-selectin, E-selectin and L-selectin. Here we show that PSGL-1 was also required for efficient homing of resting T cells to secondary lymphoid organs but functioned independently of selectin binding. PSGL-1 mediated an enhanced chemotactic T cell response to the secondary lymphoid organ chemokines CCL21 and CCL19 but not to CXCL12 or to inflammatory chemokines. Our data show involvement of PSGL-1 in facilitating the entry of T cells into secondary lymphoid organs, thereby demonstrating the bifunctional nature of this molecule.
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