Journal
EUROPEAN HEART JOURNAL
Volume 28, Issue 10, Pages 1250-1257Publisher
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehl477
Keywords
pulmonary hypertension; prognosis; magnetic resonance imaging; right ventricle
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Aims This study investigated the relationship between right ventricular (RV) structure and function and survival in idiopathic pulmonary arterial hypertension (IPAH). Methods and results In 64 patients, cardiac magnetic resonance, right heart catheterization, and the six-minute walk test (6MWT) were performed at baseline and after 1-year follow-up. RV structure and function were analysed as predictors of mortality. During a mean follow-up of 32 months, 19 patients died. A low stroke volume (SV), RV dilatation, and impaired left ventricular (LV) filling independently predicted mortality. In addition, a further decrease in SV, progressive RV dilatation, and further decrease in LV end-diastolic volume (LVEDV) at 1-year follow-up were the strongest predictors of mortality. According to Kaplan-Meier survival curves, survival was lower in patients with an inframedian SV index <= 25 mL/m(2), a supramedian RV end-diastolic volume index >= 84 mL/m(2), and an inframedian LVEDV <= 40 mL/m2. Conclusions The RV contains prognostic information in IPAH. A large RV volume, low SV, and a reduced LV volume are strong independent predictors of mortality and treatment failure.
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