Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 12, Issue -, Pages 4536-4546Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/2408
Keywords
DNA triplex; autosomal dominant polycystic kidney disease; tuberous sclerosis complex; sickle cell disease; persistence of fetal hemoglobin; Friedreich's ataxia; lymphoma; review
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Funding
- NIDDK NIH HHS [DK061458] Funding Source: Medline
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Mutagenesis is the fulcrum for the balance between the fidelity of the genetic code and evolution. While there are an enormous number of extrinsic factors driving mutagenesis, alternative DNA secondary structure is one of the intrinsic components that impacts regional genomic stability. Some alternative DNA structures are associated with human diseases, and this review focuses on disease-associated polypurine.polypyrimidine mirror repeat sequences.
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