Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 27, Issue 5, Pages 894-908Publisher
SAGE PUBLICATIONS INC
DOI: 10.1038/sj.jcbfm.9600403
Keywords
cytokines; hemorrhagic stroke; leukocytes; microglia; reactive oxygen species
Categories
Funding
- NCCIH NIH HHS [AT001836, AT002113] Funding Source: Medline
- NIAAA NIH HHS [AA014911] Funding Source: Medline
- NIA NIH HHS [R01 AG022971] Funding Source: Medline
- NINDS NIH HHS [R01 NS046400, NS046400] Funding Source: Medline
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Intracerebral hemorrhage ( ICH) is a devastating clinical event without effective therapies. Increasing evidence suggests that inflammatory mechanisms are involved in the progression of ICH-induced brain injury. Inflammation is mediated by cellular components, such as leukocytes and microglia, and molecular components, including prostaglandins, chemokines, cytokines, extracellular proteases, and reactive oxygen species. Better understanding of the role of the ICH-induced inflammatory response and its potential for modulation might have profound implications for patient treatment. In this review, a summary of the available literature on the inflammatory responses after ICH is presented along with discussion of some of the emerging opportunities for potential therapeutic strategies. In the near future, additional strategies that target inflammation could offer exciting new promise in the therapeutic approach to ICH.
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