Journal
CELLULAR AND MOLECULAR NEUROBIOLOGY
Volume 27, Issue 3, Pages 263-270Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10571-007-9139-z
Keywords
nitric oxide; blood-brain barrier (BBB); permeability; P-glycoprotein; mouse brain endothelial cells
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1. The present study aimed at elucidating the effect of nitric oxide (NO) on blood-brain barrier (BBB) function with mouse brain capillary endothelial (MBEC4) cells. 2. Histamine (20-100 mu M) evoked NO production (1.6-7 mu M) in MBEC4 cells in a dose-dependent manner. 3. The permeability coefficient of sodium fluorescein for MBEC4 cells and the cellular accumulation of rhodamine 123 in MBEC4 cells were increased dose-dependently by the addition of NO solutions (14 and 28 mu M) every 10 min during a 30-min period. 4. The present study demonstrated that NO increased the permeability and inhibited the P-glycoprotein efflux pump of brain capillary endothelial cells, suggesting that NO plays an inhibitory role in the dynamic regulation of the BBB function.
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