Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1773, Issue 5, Pages 642-652Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2006.07.001
Keywords
cell motility; Lamellipodia; Invadopodia; WASP family; cofilin; cortactin
Categories
Funding
- NCI NIH HHS [P01 CA100324, CA100324] Funding Source: Medline
- NIGMS NIH HHS [R01 GM038511, GM38511] Funding Source: Medline
Ask authors/readers for more resources
Malignant cancer cells utilize their intrinsic migratory ability to invade adjacent tissues and the vasculature, and ultimately to metastasize. Cell migration is the sum of multi-step processes initiated by the formation of membrane protrusions in response to migratory and chemotactic stimuli. The driving force for membrane protrusion is localized polymerization of submembrane actin filaments. Recently, several studies revealed that molecules that link migratory signals to the actin cytoskeleton are upregulated in invasive and metastatic cancer cells. In this review, we summarize recent progress on molecular mechanisms of formation of invasive protrusions used by tumor cells, such as lamellipodia and invadopodia, with regard to the functions of key regulatory proteins of the actin cytoskeleton; WASP family proteins, Arp2/3 complex, LIM-kinase, cofilin, and cortactin. (c) 2006 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available