Journal
AMERICAN JOURNAL OF PATHOLOGY
Volume 170, Issue 5, Pages 1535-1545Publisher
ELSEVIER SCIENCE INC
DOI: 10.2353/ajpath.2007.060478
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Funding
- NCI NIH HHS [CA09746, CA36727, R01 CA057362, CA57362, P30 CA036727] Funding Source: Medline
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Fibulin-2, an extracellular matrix protein expressed by normal epithelia, was found to be down-regulated in several breast cancer cell lines. Fibulin-2 protein expression was also decreased in breast cancer tissue samples as evaluated by immunohistochemistry. Reintroduction of Fibulin-2 into breast cancer cell lines that do not express Fibulin-2 reduced cancer cell motility and invasion in vitro but had no effect on cell growth and adhesion properties. Together with evidence that Fibulin-2 contributes to wound healing and inhibits smooth muscle cell migration, our findings suggest that loss of Fibulin-2 expression may facilitate migration and invasion in breast cancer.
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