Journal
PRESSE MEDICALE
Volume 36, Issue 5, Pages 808-809Publisher
MASSON EDITEUR
DOI: 10.1016/j.lpm.2007.02.011
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Introduction > Subacute thyroiditis (SAT) is a spontaneously remitting inflammatory disorder of the thyroid that is presumed to be virally induced in genetically predisposed individuals. A strong association has been suggested between human leukocyte antigen (HLA)-B35 and patients who developed SAT. However, familial occurrence of SAT associated with HLA-B35 is reported only rarely. Case-reports > We report three sibs, (two brothers and one sister) living in the same Lebanese town, who developed SAT during an 18-month-period. All tested positive for HLA-B35. Discussion > The family described here represents the first Third world third familial report of SAT associated with HLA-B35. It highlights the probably underestimated importance of genetic predisposition to SAT in families.
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