Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 50, Issue 9, Pages 1999-2002Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm070088s
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Funding
- NIAID NIH HHS [AI058241] Funding Source: Medline
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We have identified five derivatives of the natural product sansalvamide A that are potent against multiple drug-resistant colon cancer cell lines. These analogs share no structural homology to current colon cancer drugs, are cytotoxic at levels on par with existing drugs treating other cancers, and demonstrate selectivity for drug-resistant colon cancer cell lines over noncancerous cell lines. Thus, we have established sansalvamide A as a privileged structure for treating multiple drug-resistant colon cancers.
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