4.3 Article

Asymmetric trifluoromethylation of ketones with (trifluoromethyl)trimethylsilane catalyzed by chiral quaternary ammonium phenoxides

Journal

CHEMISTRY LETTERS
Volume 36, Issue 5, Pages 666-667

Publisher

CHEMICAL SOC JAPAN
DOI: 10.1246/cl.2007.666

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Asymmetric trifluoromethylation of ketones with (trifluoromethyl)trimethylsilane catalyzed by cinchonidine-derived quaternary ammonium phenoxides proceeded smoothly to afford the trifluoromethylated compounds in high yields with moderate to high enantioselectivities.

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