Efficient method for dehydration condensation using pyridine-3-carboxylic anhydride (3-PCA): Synthesis of carboxamides from nearly equimolar amounts of carboxylic acids and amines

A highly useful method for the preparation of carboxamides from various carboxylic acids and amines is established by using pyridine-3-carboxylic anhydride (3-PCA) in the presence of 4-(dimethylamino)pyridine (DMAP). This reaction proceeds smoothly under mild conditions by simple experimental procedure.