Journal
CHEMBIOCHEM
Volume 8, Issue 7, Pages 775-780Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200600554
Keywords
cations; DNA structures; G quadruplexes; inhibitors; phthalocyanine
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Water-soluble octacationic zinc phthalocyanine (Zn Pc) was found to be a very good G-quadruplex DNA stabilizer by using UV-melting studies and DNA polymerase stop assays, and a potent telomerase inhibitor by using the telomeric repeat amplification protocol (TRAP) assay. The compound's DNA-binding properties were also studied by surface plasmon resonance (SPR). Furthermore, CD experiments demonstrated that ZnPc could induce intramolecular G-quadruplex structure transition from the antiparallel to parallel form. More importantly, ZnPc was found to induce parallel structure formation in cation-deficient conditions. The stability of the induced structure was determined with CD melting assays.
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