Journal
TETRAHEDRON LETTERS
Volume 48, Issue 19, Pages 3455-3458Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.03.033
Keywords
solid phase synthesis; microwave heating; Imatinib; Gleevec; chronic myeloid leukaemia
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An expeditious, high yield and convenient synthesis of Imatinib was carried out on an aldehydic, super acid-sensitive resin, through an efficient, micro wave-assisted synthetic protocol. The high versatility of the reaction scheme may enable the straightforward preparation of libraries of potential protein kinase inhibitors endowed with large molecular diversity. (c) 2007 Elsevier Ltd. All rights reserved.
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