Journal
JOURNAL OF NEUROSCIENCE
Volume 27, Issue 19, Pages 5260-5264Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0018-07.2007
Keywords
endocannabinoid; striatum; synaptic plasticity; basal ganglia; dopamine; LTD
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Endocannabinoid (eCB)-mediated forms of long-term synaptic plasticity occur in several brain regions, but much remains unknown about their basic properties and underlying mechanisms. Here, we present evidence that eCB-mediated long-term depression (eCB-LTD) at excitatory synapses on medium spiny neurons in the striatum requires presynaptic activity coincident with CB1 receptor activation. This dual requirement for CB1 activation and presynaptic activity is a mechanism by which eCB-LTD may be made synapse specific.
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