Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 44, Issue 1, Pages 279-282Publisher
ELSEVIER
DOI: 10.1016/j.jpba.2007.02.004
Keywords
arbutin; kojic acid; hydroquinone; cosmetics; experimental design; CE
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A statistical experimental design was used to optimize one micellar electrokinetic capillary electrophoresis (MEKC) for simultaneous analysis of arbutin (AR), kojic acid (KA) and hydroquinone (HQ). Untreated fused-silica capillaries were operated using a phosphate buffer (20 mM, pH 6.5) under 20 kV and detection at 200 nm. Quantitative linear ranges were 20-200 mu g/ml for AR, 20-100 mu g/ml for KA and 8-80 mu g/ml for HQ with correlation coefficients >= 0.9994. R.S.D. and R.E. were less than 3.0% for the intra-day and inter-day analysis, and all recoveries were greater than 99%. Our method was applied to assay commercial cosmetics. The results were within the labeled amount of 99.6-102.5%. (c) 2007 Elsevier B.V. All rights reserved..
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