Journal
MACROMOLECULAR BIOSCIENCE
Volume 7, Issue 5, Pages 671-680Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200600281
Keywords
drug biotransformation; human hepatocytes; membrane bioreactor; morphology; synthetic functions
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The viability and liver specific functions of human hepatocytes in a multibore fiber bioreactor are reported. Human hepatocytes were cultured in the intraluminal compartment of the bioreactor. Human hepatocytes on the membranes maintained their round shape and showed focal adhesions as sites of interaction with the membrane surface. Cells in the bioreactor expressed liver specific functions, including synthetic and detoxification activity up to 14 d of culture. The results demonstrate that human hepatocytes cultured in the multibore fiber bioreactor are able to sustain the same in vivo liver functions in vitro.
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